This book originated from a series of papers which were published in “Die Naturwissenschaften” in Its division into three parts is the reflection of a . It is suggested that the concept of a hypercycle should be formally M. Eigen. Naturwissenschaften, 58 (), p. Eigen et al., “more RNA in replicators”. BOTH. FIRST more replicators: ecosystem based solution. Hypercycles (Eigen’s original solution). Emergence of higher levels of.

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After formation, a hypercycle reaches either an internal equilibrium or a state with oscillating concentrations of each type of chain Ibut with the total concentration of all chains remaining constant. After that, the whole individualized and compartmentalized hypercycle can behave like a simple self-replicating entity.

Both conditions eigdn very improbable; therefore, the existence of coupled hypercycles is assumed impossible in practice. Instead, only the contaminated compartment is destroyed, without affecting other compartments.

Moreover, Vaidya et al. Journal of Biological Chemistry.

Retrieved from ” https: Unfortunately, in this case, rotation decelerates as the number of hypercycle members increases, meaning that selection tends toward decreasing the amount of information stored in the hypercycle.

Finally, the membrane surface can work as a catalyst.

The scheme is basically as follows: Schuster proposed the model of hypercycles [1], as a hypothetical stage of macromolecular evolution, which could follow quasispecies. The dynamics of the elementary hypercycle can be modelled using the following differential equation: The extinction of the hypercycle then follows.

This problem is known as the error threshold problem. In other projects Wikimedia Commons. The above-described idea of a hypercycle’s robustness results from an exponential growth of its constituents caused by the catalytic support. At the same time, harmful mutations cannot pollute the entire system if they are enclosed by the membrane. Physics of Life Reviews. Carsten Bresch and coworkers raised an objection that hypercyclic organization is not necessary if compartments are taken into account.


An RNA ligase, in turn, could link various components of quasispecies into one chain, beginning the process of a genome integration. After one hypercycle wins the competition, it is very unlikely that another one could take its place, even if the new hypercycle would be more efficient than the winner.

Computational and Mathematical Methods in Medicine. The replication enzymes ensure the more accurate RNAs’ replication as compared with quasispecies, providing opportunities for further macromolecular structure improvements. Moreover, it was shown that compartmentalized hypercycles are more sensitive to the input of deleterious mutations than a simple package of competing genes.

However, it was hypothesized that even if the putative first RNA-dependent RNA-polymerases are estimated to be longer—the smallest reported up-to-date RNA-dependent polymerase ribozyme is nucleotides long [18] —they did not have to arise in one step. This, first, makes the system resistant to so-called parasitic branches. However, as pointed out by the authors, such packages are—contrary to hypercycles—vulnerable to deleterious mutations as well as a fluctuation abyss, resulting in packages that lack one of the essential RNA molecules.

Hypercycle theory proposed that hypercycles are not the final state of organization, and further development of more complicated systems is possible by enveloping the hypercycle in some kind of membrane. Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena”.

It was also emphasized that a hypercycle size of up to four is too small to maintain the amount of information sufficient to cross the information threshold.

The Stochastic Corrector Model vs.

The hypercycle. A principle of natural self-organization. Part A: Emergence of the hypercycle.

The reason for hhpercycle to survive is the lack of mutual control of constituent abundances. From Wikipedia, the free encyclopedia. Furthermore, each molecule is additionally a subject for self-replication. Over the years, the hypercycle theory has experienced many reformulations and methodological approaches. In that way, compartmentalization allows for selection for genotypic mutations. A bioinformatic approach to the origin of life”. Nevertheless, hypeercycle both alternative concepts, the system will not survive due to the internal competition among its constituents.



The theory of evolution and dynamical systems: It supports a peptidyl-RNA synthesis that could be a precursor for the contemporary process of linking amino acids to tRNA molecules. In his principal work, Manfred Eigen stated that the E coded by the I chain can be a specific polymerase or an enhancer or a silencer of a more hypeecycle polymerase acting in favour of formation of the successor of nucleotide chain I.

More than thirty years after the introduction of the hypothesis, there is no experimental evidence whatsoever for complex, possibly prebiotic hypercycles.

Without this feedback loop, the replicating system would be lost.

Hypercycle (chemistry)

As such, it explained how life on Earth could have begun using only relatively short genetic sequenceswhich in theory were too short to store all essential information. Advances in Complex Systems. Hypercycle elements should be simultaneously catalysts enzymes and replicators.

These results were also explained analytically by the ODE model and its analysis. Eigen made several assumptions about conditions that led to the formation of the first hypercycles.

Nowadays, taking into hyperctcle the knowledge about ribozymes, it may be possible that a hypercycle’s members were selected from the quasispecies population and the enzymatic function was performed by RNA. The primary of them was that the formation of hypercycles had required the availability of both types of chains: Vasil’ev [2], who modeled a hypercycles competition in coacervate-type compartments.

The proposed model consists of a number of nucleotide sequences I I stands for intermediate and the same number of polypeptide chains E Eiben stands for enzyme.